Lipoxygenase Inhibition Activity of Coumarin Derivatives—QSAR and Molecular Docking Study
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چکیده
منابع مشابه
Cholinesterase Inhibition Activity and Docking Simulation Study of Coumarin Mannich Base Derivatives
Inhibition of acetylcholinesterase and butyrylcholinesterase (AChE and BuChE) as two major forms of cholinesterases (ChEs) is considered as the common approach for the treatment of Alzheimer's disease (AD). The present study was done to explore the anticholinesterase inhibition property of coumarin Mannich base derivatives. A series of cumarin Manich bases were synthesized (4a-h) through one-po...
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Alzheimer's disease is an irreversible and progressive brain disorder that slowly destroys memory and thinking skills and ultimately the ability to do the simplest things and can lead to death. Cholinesterases (ChEs) play an important role in controlling cholinergic transmission, and subsequently, by inhibiting CHEs, acetylcholine levels in the brain are elevated. Coumarins have been shown to e...
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During the last 2 decades, the study of the biological activities of Coumarin derivatives has been the aim of many researchers. Based on these findings, a series of Coumarin substituted benzothiazoles were synthesized by refluxing Coumarin-4-carboxaldehyde and oaminothiophenol in acetic acid. Compounds were characterized by IR, 1H NMR and mass spectroscopy. All the compounds were tested for the...
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In search of potent cholinesterase inhibitors, we have carried out the synthesis and biologically evaluation of various benzaldehyde based 2,3-dihydroquinazolin-4(1H)-one derivatives. In vitro assay results revealed that all the synthesized compounds showed activity against both enzymes (AChE and BChE) and in few cases, the inhibition activity was even higher than or comp...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2020
ISSN: 1424-8247
DOI: 10.3390/ph13070154